Proposed pathogenesis of pain in patients with primary LPHS

Note that the proposed mechanism is initiated by glomerular hematuria.

GBM: glomerular basement membrane.

Reproduced with permission: Spetie DN, Nadasdy T, Nadasdy G, Agarwal G, Mauer M, Agarwal AK, Khabiri H, Nagaraja, HN, Nahman Jr NS, Hartman JA, Hebert LA: Proposed pathogenesis of idiopathic loin pain-hematuria syndrome. Am J Kidney Dis 47(3):419-427, 2006. Copyright © 2006 National Kidney Foundation.