A genetic model for colorectal tumorigenesis

ACF: aberrant crypt foci; APC: adenomatous polyposis coli gene; DCC: deleted in colon cancer gene; LOH: loss of heterozygosity; MMR: DNA mismatch repair enzyme.

Adapted from: Lynch, JP, Hoops, TC. The genetic pathogenesis of colorectal cancer. Hematol Oncol Clin North Am 2002; 16:775.

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