In the Women's Health Initiative, combined estrogen-progestin replacement therapy was associated with significant reduction in hip fracture (five fewer hip fractures per 10,000 person-years; HR 0.7, unadjusted 95% CI 0.4-1.0).
HR: hazard ratio.
Data from: Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen and progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002; 288:321.