Gene/polymorphism | Effect/association | Theoretical mechanism | Ref. |
LTA + 80 | Parasitemia reduction | Lymphotoxin production | [1] |
GNAS | Severe malaria | Red cell signaling; invasion inhibition | [2] |
iNOS | Severe malaria | Decreased iNOS | [3] |
Pyruvate kinase | Infection | Unknown | [4] |
ABO glycosyltransferase | Severe malaria anemia | Decreased resetting of red blood cells | [5] |
Toll-like receptors (TLR-1, -6, and -9) | Malaria and high parasitemia | Innate immunity | [6] |
FLT1 | Placental malaria | Unknown | [7] |
TIM1 | Cerebral malaria | Induction of Th2 antiinflammatory responses | [8] |
IL-10 | Severe malaria anemia | Antiinflammatory activity of enhanced IL-10 production | [9] |
CR-1 (promoter) | Cerebral malaria | Increased clearance of infected cells | [10,11] |
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