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Red blood cell abnormalities in hereditary spherocytosis: role of the spleen

Red blood cell abnormalities in hereditary spherocytosis: role of the spleen
RBC property Controls HS HS-Splenect
Number of subjects 37 25 23
Hemoglobin (g/dL) 13.9±1.0* 12.2±1.5 15.2±1.3
Reticulocytes (percent) 1.0±0.3 6.7±3.5 2.1±1.0
MCHC reticulocytes (g/dL) 26.6±1.3 30.2±2.5 31.2±1.2
MCHC mature RBC (g/dL) 32.2±0.7 36.1±1.6 36.1±0.8
RBC: red blood cells; HS: hereditary spherocytosis; HS-Splenect: splenectomized patients with HS; MCHC: mean corpuscular hemoglobin concentration.
* Values are mean ±1 standard deviation.
Note that splenectomy corrected the anemia and reduced the reticulocyte percentage almost to normal in patients with HS, but did not alter the spherocytic changes, as reflected by the increased values for MCHC, either in the reticulocytes or the mature red cells.
Data from: Da Costa L, Mohandas N, Sorette M, et al. Temporal differences in membrane loss lead to distinct reticulocyte features in hereditary spherocytosis and in immune hemolytic anemia. Blood 2001; 98:2894.
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