Major criteria |
Exclusion of other known causes of ILD such as certain drug toxicities, environmental exposures, and connective tissue diseases |
Abnormal pulmonary function studies that include evidence of restriction (reduced VC, often with an increased FEV1/FVC ratio) and impaired gas exchange [increased P(A-a)O2, decreased PaO2 with rest or exercise or decreased DLco] |
Bibasilar reticular abnormalities with minimal ground glass opacities on HRCT scans |
Transbronchial lung biopsy or BAL showing no features to support an alternative diagnosis |
Minor criteria |
Age >50 years |
Insidious onset of otherwise unexplained dyspnea or exertion |
Duration of illness >3 months |
Bibasilar, inspiratory crackles (dry or "Velcro"-type in quality) |
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