Moran[1] (2000) | WHO[2] (2004) WHO[3] (2015) | WHO[4] (2000) | Hochwald[5] (2002) AFIP[6] (2007) | WHO[7] (2004) | ENETS[8,9] (2006) AJCC[10] (2009) WHO[11] (2010) | WHO[12] (2019) | ||
Organ system | Thymus | Lung, thymus | GI | Pancreas | Pancreas | GI, pancreas | GI, pancreas, hepatobiliary | |
Mitotic index | G1 | <3/10 HPF | <2/2 mm2 | NA | <2/50 HPF | <2/2 mm2 | <2/2 mm2 | <2/2 mm2 |
G2 | 4 to 9/10 HPF | 2 to 10/2 mm2 | NA | 2 to 10/50 HPF | 2 to 10/2 mm2 | 2 to 20/2 mm2 | 2 to 20/2 mm2 | |
G3 | NA | NA | NA | NA | NA | >20/2 mm2 | >20/2 mm2 | |
Ki-67 | G1 | NA | NA | NA | NA | <2% | ≤2% (<3%) | <3% |
G2 | NA | NA | NA | NA | >2% | 3 to 20% | 3 to 20% | |
G3 | NA | NA | NA | NA | NA | >20% | >20% | |
Other parameters | Necrosis | Necrosis | Size, invasion, metastasis | Necrosis | Size, invasion, metastasis | None | Assessment of morphology and marker expression helps to differentiate from poorly differentiated neuroendocrine carcinoma |
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