Recommend annual MRI screening (based on high risk of breast cancer and high sensitivity of MRI*) |
BRCA mutation |
First-degree relative of BRCA carrier, but untested |
Lifetime risk >20 to 25% or greater, as defined by BRCAPRO or other models that are largely dependent on family history |
Recommend annual MRI screening (based on high risk of breast cancer) |
Radiation to chest between age 10 and 30 years |
Li-Fraumeni syndrome and first-degree relatives |
Cowden and Bannayan-Riley-Ruvalcaba syndromes and first-degree relatives |
Insufficient evidence to recommend for or against MRI screeningΔ |
Lifetime risk 15 to 20%, as defined by BRCAPRO or other models that are largely dependent on family history |
Lobular carcinoma in situ or atypical lobular hyperplasia |
Atypical ductal hyperplasia |
Heterogeneously or extremely dense breast on mammography |
Women with a personal history of breast cancer, including ductal carcinoma in situ |
Recommend against MRI screening (based on expert consensus opinion) |
Women at <15% lifetime risk |
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