Component (volume) | Contents | Indications and dose |
Whole blood (1 unit = 500 mL)* | RBCs, platelets, plasma |
|
RBCs in additive solution (1 unit = 350 mL) | RBCs |
|
FFP or other plasma product¶ (1 unit = 200 to 300 mL) | All soluble plasma proteins and clotting factors |
|
Cryoprecipitate, also called "cryo" (1 unit = 10 to 20 mL) | Fibrinogen; factors VIII and XIII; VWF |
|
Platelets (derived from whole blood or apheresis) (1 unit of apheresis platelets or a 5 to 6 unit pool of platelets from whole blood = 200 to 300 mL) | Platelets |
|
DIC: disseminated intravascular coagulation; FFP: Fresh Frozen Plasma; PCC: prothrombin complex concentrate; RBCs: red blood cells; TTP: thrombotic thrombocytopenic purpura; VWF: von Willebrand factor.
* 450 mL blood and 63 mL citrate-phosphate-dextrose (CPD) anticoagulant-preservative solution.
¶ Other plasma products include:PF24 may be used interchangeably with FFP for all of the indications listed above, with the exceptions of factor VIII deficiency or protein C deficiency, which are treated with recombinant products or plasma-derived factor concentrates. In the rare event that specific factor concentrates are unavailable and these deficiencies must be treated with a plasma product, FFP should be used.
Thawed Plasma may be used interchangeably with FFP for all of the indications listed above, with the exception of factor VIII deficiency without access to factor VIII concentrates, in which FFP should be used, or factor V deficiency, in which FFP or PF24 should be used.Do you want to add Medilib to your home screen?