Autoimmune thyroiditis - Established serological or tissue diagnosis
- Diffuse goiter
- Previous Graves' disease, de Quervain thyroiditis, or painless (postpartum) thyroiditis
- Family history of autoimmune thyroid disease
- Down syndrome
- Turner syndrome
- Personal or family history of associated autoimmune disorders (eg, vitiligo, pernicious anaemia, adrenal insufficiency, diabetes mellitus type 1, ovarian failure, celiac disease, Sjögren syndrome)
- Primary pulmonary hypertension
- Multiple sclerosis
- Thyroidectomy or other neck surgery
- Radioactive iodine therapy
- External radiotherapy
- Exposure to polybrominated and polychlorinated biphenyls, and resorcinol
| Drugs impairing thyroid function - Lithium carbonate
- Amiodarone
- Aminoglutethimide
- Interferon alfa
- Thalidomide
- Betaroxine
- Stavudine
- Hypothalamic or suprasellar mass
- History of hypothalamic radiotherapy or surgery
- Disorders causing hypothalamic dysfunction (eg, sarcoidosis, hemochromatosis, Langerhans cell histiocytosis)
- Known pituitary tumour
- Other elements of hypopituitarism
- Manifestations of a sellar mass (eg, headache, bitemporal hemianopsia, or diplopia)
- History of pituitary surgery of radiotherapy
- History of head trauma
- History of pituitary apoplexy, including Sheehan syndrome
- History of other disorders causing hypopituitarism (eg, metastatic cancer and lymphocytic hypophysitis)
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