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Characteristics of oral thyroid hormone preparations available in the United States

Characteristics of oral thyroid hormone preparations available in the United States
Generic name Composition Brand names* Average adult dose/day (oral)
Levothyroxine T4 Tablets:Δ Euthyrox, Levoxyl, Synthroid, Unithroid 112 to 125 mcg
Soft gel capsules: Tirosint
Oral solutions:§ Ermeza, Tirosint-Sol, Thyquidity
Liothyronine T3 Tablets:¥ Cytomel 37.5 mcg
Desiccated thyroid extract
(Thyroid USP)
4:1 mixture of T4 and T3 (approximately) Tablets: Adthyza, Armour Thyroid, Niva Thyroid, NP Thyroid 90 mg
1 grain of desiccated thyroid extract (60 mg) should contain approximately 38 mcg T4 and 9 mcg T3
Pork origin

T3: triiodothyronine; T4: thyroxine.

* Generic preparations may also be available.

¶ Best preparation.

Δ Available in tablet strengths from 25 to 300 mcg.

◊ Available in capsule strengths from 13 to 200 mcg.

§ Ermeza is available as a 150 mcg/5 mL oral solution (75 or 150 mL per bottle). Tirosint-Sol is supplied in 1 mL unit dose ampules of varying concentrations from 13 to 200 mcg/mL. Thyquidity is available as a 100 mcg/5 mL oral solution (100 mL per bottle).

¥ Available in tablet strengths of 5, 25, and 50 mcg.

‡ Dose reserved for patients with differentiated thyroid cancer undergoing levothyroxine withdrawal before radioiodine therapy.

† Available in tablet strengths from 15 to 300 mg.
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