Non-invasive high-grade papillary urothelial carcinoma (HGPUC)

At low power (A, 20x) HGPUC shows a pattern of disorder with easily recognizable architectural and cytologic variation. The papillae are frequently fused and branching. At high power (B-C, 40x) there is moderate to marked pleomorphism. The chromatin tends to be clumped, the nucleoli may be prominent, the thickness of the urothelium may vary considerably, and mitoses are often present.