Definitive diagnosis* |
A male or female patient with decreased intensity of expression of CD18 on neutrophils (less than 5% of normal) and at least one of the following: |
1. Mutation in the beta-2 integrin gene. |
2. Absence of beta-2 integrin mRNA in leukocytes. |
Probable diagnosis* |
A male or female patient with defective expression of CD18 on leukocytes (less than 5% of normal) and all of the following: |
1. Recurrent or persistent bacterial or fungal infections. |
2. Leukocytosis (WBC greater than 25,000/mm3). |
3. Delayed separation of the umbilical cord and/or defective wound healing. |
Possible diagnosis* |
Infant with marked leukocytosis (WBC greater than 25,000/mm3) and one of the following: |
1. Recurrent bacterial infections. |
2. Severe deep-seated infection. |
3. Absence of pus at sites of infection. |
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