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Mechanisms of glomerular damage

Mechanisms of glomerular damage
Schematic depiction of the major mechanisms by which immune events lead to damage of the glomerular filtration barrier.
Th: T helper cell; IgG: immunoglobulin G; MBL: Mannan-binding lectin; MAC: membrane attack complex; GEC: glomerular epithelial cell; GEN: glomerular endothelial cell; MC: mesangial cell; GBM: glomerular basement membrane; TLR: toll-like receptors; MP: macrophage; PMN: polymorphonuclear cell; NK: natural killer cell; PLT: platelet.
Courtesy of Ramòn G.B. Bonegio, MBBCh, PhD.
Graphic 52652 Version 5.0