Estimated osmolal concentration of common organic intoxicants
Estimated osmolal concentration of common organic intoxicants
Solvent
Concentration (mg/dL) per 1 mosmol/kg elevation in osmolal gap
Ethanol
4.0[1]
Methanol
3.2
Ethylene glycol
6.2
Acetone
5.8
Isopropanol
6.0
Reference:
Garrard A, Sollee DR, Butterfield RC, et al. Validation of a pre-existing formula to calculate the contribution of ethanol to the osmolar gap. Clin Toxicol (Phila) 2012; 50:562.
Adapted from: Kulig K, Duffy JP, Linden CH, et al. Toxic effects of methanol, ethylene glycol, and isopropyl alcohol. Top Emerg Med 1984; 6:16.