Cancer site | MLH1 | MSH2Δ | MSH6 | PMS2 | ||||||||
Female | Male | Both | Female | Male | Both | Female | Male | Both | Female | Male | Both | |
Any Lynch cancer | 71 to 81% | 71 to 72% | 71 to 90% | 61 to 84% | 52 to 75% | 52 to 84% | 62 to 65% | 41 to 47% | 58 to 73% | – | – | 34 to 52% |
Colorectal | 35 to 57% | 39 to 78% | 35 to 90% | 26 to 68% | 31 to 63% | 52 to 84% | 20 to 30% | 12 to 69% | 18 to 58% | 12 to 15% | 13 to 20% | 12 to 52% |
Endometrial | 20 to 57% | – | – | 21 to 71% | – | – | 17 to 71% | – | – | 13 to 15% | – | – |
Gastric | 3 to 15% | 6 to 37% | Up to 37% | 13 to 19% | 5 to 20% | Up to 20% | 1 to 4% | 1 to 8% | Up to 8% | – | – | Unknown* |
Ovarian | 8 to 20% | – | – | 12 to 38% | – | – | 1 to 11% | – | – | 3 to 5% | – | – |
Ureter/kidney | 2 to 5% | 4 to 5% | Up to 5% | 6 to 19% | 6 to 18% | Up to 19% | 1 to 5% | 1 to 2% | Up to 5% | – | – | Up to 4% |
Bladder | 1 to 5% | 4 to 11% | Up to 11% | 3 to 8% | 4 to 13% | Up to 13% | 1 to 2% | 1 to 8% | Up to 8% | – | – | Unknown* |
Prostate | 9 to 14% | 24 to 30% | 9 to 30% | Up to 5% | ||||||||
Breast¶ | Up to 19% | Up to 16% | Up to 14% | Up to 15% | ||||||||
Brain | Up to 2% | Up to 8% | Up to 4% | – | ||||||||
Small bowel | Up to 4% | Up to 8% | Up to 4% | Unknown* | ||||||||
Pancreatobiliary | Up to 5% | Up to 5% | Unknown* | Unknown* | ||||||||
Skin | Up to 4% | Up to 10% | Up to 4% | Unknown* |
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