Version August 2025
| Cytogenetic abnormality | Approximate percent of MGUS | Genes dysregulated by cytogenetic changes |
| Primary IgH translocations involving chromosome 14q32 (non-hyperdiploid MGUS) | ||
| t(11;14)(q13;q32) | 25% | CCND1 (cyclin D1) |
| t(4;14)(p16;q32) | 15% | FGFR-3 and MMSET/WHSC1 |
| t(14;16)(q32;q23) | 5% | C-MAF |
| t(6;14)(p21;q32) | 3% | CCND3 (cyclin D3) |
| t(14;20)(q32;q11) | 2% | MAFB |
| Hyperdiploidy (hyperdiploid MGUS) | ||
| 45% | Multiple genes dysregulated due to recurrent trisomies involving odd-numbered chromosomes with exception of chromosomes 1, 13, and 21 | |
| Unknown | ||
| <5% | Neither IgH translocation nor hyperdiploidy | |
