Primary tumor (T)* | ||||
TX | Primary tumor cannot be assessed | |||
T0 | No evidence of primary tumor | |||
Tis | High-grade dysplasia¶ | |||
T1 | Tumor invades lamina propria, muscularis mucosae, or submucosa | |||
T1a | Tumor invades lamina propria or muscularis mucosae | |||
T1b | Tumor invades submucosa | |||
T2 | Tumor invades muscularis propria | |||
T3 | Tumor invades adventitia | |||
T4 | Tumor invades adjacent structures | |||
T4a | Resectable tumor invading pleura, pericardium, or diaphragm | |||
T4b | Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. | |||
Regional lymph nodes (N)Δ | ||||
NX | Regional lymph node(s) cannot be assessed | |||
N0 | No regional lymph node metastasis | |||
N1 | Metastasis in 1-2 regional lymph nodes | |||
N2 | Metastasis in 3-6 regional lymph nodes | |||
N3 | Metastasis in seven or more regional lymph nodes | |||
Distant metastasis (M) | ||||
M0 | No distant metastasis | |||
M1 | Distant metastasis | |||
Histologic grade (G) | ||||
GX | Grade cannot be assessed - stage grouping as G1 | |||
G1 | Well differentiated | |||
G2 | Moderately differentiated | |||
G3 | Poorly differentiated | |||
G4 | Undifferentiated - stage grouping as G3 squamous | |||
Anatomic stage/prognostic groups | ||||
Adenocarcinoma carcinoma | ||||
Stage | T | N | M | Grade |
0 | Tis (HGD) | N0 | M0 | 1, X |
IA | T1 | N0 | M0 | 1-2, X |
IB | T1 | N0 | M0 | 3 |
T2 | N0 | M0 | 1-2, X | |
IIA | T2 | N0 | M0 | 3 |
IIB | T3 | N0 | M0 | Any |
T1-2 | N1 | M0 | Any | |
IIIA | T1-2 | N2 | M0 | Any |
T3 | N1 | M0 | Any | |
T4a | N0 | M0 | Any | |
IIIB | T3 | N2 | M0 | Any |
IIIC | T4a | N1-2 | M0 | Any |
T4b | Any | M0 | Any | |
Any | N3 | M0 | Any | |
IV | Any | Any | M1 | Any |
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