GLP-1 | GIP | |
Site of synthesis | Small intestinal L cells | Small intestinal K cells |
Glucose-dependent stimulation of insulin secretion | Yes | Yes |
Reduction of gastric emptying | Yes | No effect |
Reduction of inappropriate glucagon secretion | During euglycemia or hypoglycemia: No effect During hyperglycemia: Suppresses glucagon | During euglycemia or hypoglycemia: Stimulates glucagon During hyperglycemia: No effect |
Weight loss | Yes | Yes |
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