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Sulfonylureas with significant renally-eliminated, active metabolites

Sulfonylureas with significant renally-eliminated, active metabolites
Sulfonylurea Active, renally-eliminated metabolite
Acetohexamide Hydroxyhexamide, 65 percent
Chlorpropamide

Chlorpropamide, 20 percent

2-Hydroxychlorpropamide, 55 percent

Tolazamide

Hydroxytolazamide, 35 percent

Tolazamide, 7 percent

Tolbutamide Hydroxytolbutamide, 30 percent
Glimepiride Cyclohexylhydroxymethyl derivative, 63 percent
Glyburide 4-hydroxyglyburide, 36 percent
Sulfonylurea_renal_metab.htm
Data from: Bosse, GM. Antidiabetes and Hypoglycemics. In: Goldfrank's Toxicologic Emergencies, 8th Edition, Goldfrank, LR, Flomenbaum, NE, Hoffman, RS, et al (Eds), McGraw Hill, New York 2006. p. 749.
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