Human rabies vaccine | Product name | Manufacturer | Potency | Dose | Route | Indications |
Human diploid cell vaccine | Imovax Rabies | Sanofi Pasteur 800-822-2463 https://www.sanofi.com/en/ | N/A | 1 mL | Intramuscular | Pre-exposure or post-exposure |
Purified chick embryo cell vaccine | RabAvert | Bavarian Nordic 866-378-5237 https://www.bavarian-nordic.com/ | N/A | 1 mL | Intramuscular | Pre-exposure or post-exposure |
Rabies immune globulin | Imogam Rabies-HT | Sanofi Pasteur 800-822-2463 https://www.sanofi.com/en/ | 150 international units/mL | 20 international units/kg | Local* | Post-exposure only |
HyperRAB¶ | Grifols Therapeutics, Inc 888-474-3657 https://www.grifols.com/en/home | 300 international units/mL | 20 international units/kg | Local* | Post-exposure only | |
KEDRAB[1] | Kedrion BioPharma and Kamada, Ltd 855-353-7466 https://www.kedrion.us/ | 150 international units/mL | 20 international units/kg | Local* | Post-exposure only |
* As much of the product as is anatomically feasible should be infiltrated into and around the wound. Any remaining RIG should be administered in the deltoid muscle contralateral to the vaccine dose. If there is no obvious wound (eg, suspected bat exposure), the entire volume of RIG should be administered IM, preferably into the anterolateral thigh or the deltoid muscle contralateral to the vaccine dose. Injection into the gluteus muscle should be avoided as it carries the risk for sciatic nerve damage.
¶ The Grifols HyperRab 300 international units/mL product should be diluted with D5W rather than saline, if necessary, to provide adequate volume for wound infiltration with careful attention to assure the recommended dose is administered.Adapted from: Manning, SE, Rupprecht, CE, Fishbein, D, et al. Human rabies prevention-United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep 2008; 57:1.
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