Source | Test | ||||
Fungal culture | Histoplasma antigen test | Anti-Histoplasma antibody* | Histopathologic examination for fungi | ||
Initial evaluation in all patients | Cerebrospinal fluid¶ | X | X | X | |
Blood | X | X | X | ||
Urine | X | ||||
Biopsy of non-CNS site (eg, bone marrow) if evidence of involvement |
X |
X | |||
Additional testing if initial evaluation is negative | Cisternal or ventricular fluidΔ | X | X | X | |
Biopsy of brain or meninges | X | X |
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