Percent of group affected | Fold increase in risk compared with general population | |
General population (United States and Europe)[1] | 0.7 to 1.0 | – |
Relatives of patient with celiac disease*[1,2] | ||
First-degree relatives | 5 to 7.5 | 5 to 11 |
Second-degree relatives | 2 to 3 | 2 to 4 |
Down syndrome[3,4] | 5 to 12 | 7 to 18 |
Type 1 diabetes[3,9] | 5 to 10 | 7 to 13 |
Autoimmune liver disease[5] | 3.6 | 6.6 |
Juvenile idiopathic arthritis[6-8] | 2 to 3 | 3 |
IgA deficiency[10] | 8 | 11 |
Autoimmune thyroid disease[3,11] | 2 to 7 | 6 (less in children) |
Turner syndrome[3] | 4 to 8 | 5 to 11 |
Williams syndrome[12] | 8 | 11 |
IgA: immunoglobulin A.
* The risk also varies with the relationship to the proband (eg, higher for siblings than for parents of the proband)[2].Do you want to add Medilib to your home screen?