Brushing | Broncho-alveolar lavage (BAL) | Washing | Endobronchial biopsy (EBB) | Transbronchial biopsy (TBB) | Endobronchial needle aspiration (EBNA) | Transbronchial needle aspiration (TBNA) | Additional guidance | |
Endoluminal lesion | + | - | + | +++ | - | +++ | - | AFB or NBI if lesion is not distinct on routine examination |
Paratracheal mass, mediastinal or hilar lymphadenopathy | - | - | - | - | - | - | +++ | EBUS (radial or linear probe) |
Peripheral lung mass or nodule | +/- | +/- | +/- | - | + | - | + | ENB, EBUS (radial probe), XFL |
Peripheral pulmonary infiltrate (localized) | + | ++ | + | - | ++ | - | +/- | ENB or XFL |
Diffuse pulmonary infiltrate | + | +++ | - | - | ++ | - | + |
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