Version August 2025
| Drug/substance | Typical dose | Kinetics following ingestion (refer to NOTE) | ||
| Onset (minutes) | Peak effect (hours) | Duration of effects (hours) | ||
| 25B-NBMOe | Oral (buccal) or nasal: 250 to 500 micrograms | 20 to 40 | 0.5 to 4 | 12 to 16 |
| 25C-NBOMe | Oral (buccal) or nasal: 200 to 1000 micrograms | 1 to 15 | 0.5 to 4 | 4 to 10 |
| 25I-NBOMe | Oral (buccal) or nasal: 500 to 800 micrograms | 1 to 17 | 0.5 to 2 | 6 to 10 |
| AMT (α-methyltryptamine) | Oral: 20 to 40 mg Smoked: 6 to 10 mg | 20 to 30 | 4 to 8 | 12 to 16 |
| DMT (dimethyltryptamine; N,N-dimethyltryptamine) | Oral: 35 to 75 mg IV, smoked: 30 to 150 mg | 20 to 60 | 1 to 2 | 2 to 8 |
| Dextromethorphan | Oral: 100 to 600 mg | 15 to 30 | 2.5 | 4 to 6* |
| 5-MeO-DIPT (Foxy methoxy) | Oral: 5 to 30 mg Nasal: 5 to 20 mg Smoked: 2 to 15 mg | 20 to 60 | 1 to 2 | 3 to 6 |
| Hawaiian baby woodrose (Argyreia nervosa) | Oral: 5 to 10 seeds | ND | ND | 6 to 8 |
| Ibogaine | Oral: 10 mg/kg | 45 to 120 | 4 to 8 | 18 to 24 |
| Ketamine | Oral: 200 to 300 mg IV: 50 to 100 mg IM: 75 to 125 mg Nasal: 60 to 250 mg | 15 to 20 | 0.5 to 1 | 1.5 to 2 |
| LSD (lysergic acid diethylamide) | Oral: 25 to 200 micrograms | 30 to 90 | 3 to 5 | 6 to 12 |
| Mescaline (peyote) | Oral: 200 to 500 mg (6 to 12 dried buttons) | 30 to 120 | 2 to 4 | 6 to 12 |
| Morning glory (Ipomoea violacae) | Oral: 200 to 300 seeds | 60 | ND | 6 to 10 |
| PCP (phencyclidine) | Oral: 2 to 6 mg IV, nasal, smoked: 1 to 3 mg | 30 to 60 | 1 to 4 | 4 to 6 |
| Psilocybin | Oral: 10 mg (20 to 30 g fresh mushrooms; 1 to 2 g dried mushroom powder) | 20 to 30 | 1 to 2 | 6 to 8 |
| Salvia divinorum | Oral: 1 mg (5 to 10 leaves) Smoked: 200 to 500 micrograms | 3 to 15 | 1 | 1 to 3 |
ND: no data available for this parameter.
* For rapid metabolizers (majority), who have high CYP2D6 activity; for poor metabolizers, duration of action can exceed 24 hours.