Sick infant |
Neonatal history |
Is there a history of perinatal asphyxia? |
Does the child have meconium aspiration syndrome or respiratory distress syndrome? |
Is there evidence of infection? |
Necrotizing enterocolitis |
Sepsis/DIC |
Does the child look abnormal? |
Toxoplasmosis, rubella, cytomegalovirus, herpes simplex |
Chromosome abnormality |
Is the child small for gestational age? |
Could the child have a thrombus? Were there indwelling catheters? |
Did the child have an intracranial hemorrhage? |
Maternal history |
Prenatal or perinatal infection |
Preeclampsia, hemolytic anemia, elevated liver enzymes, low platelet count |
Abnormal placenta |
Neonatal examination |
Head circumference, weight percentile |
Congenital anomalies: radial rays, thumbs, dysmorphic features |
Hepatosplenomegaly |
Blueberry muffin rash |
Hemangioma |
Neonatal laboratory values |
Abnormalities in the white blood cell count or hematocrit |
Hyperbilirubinemia or liver function test abnormalitites |
Evidence of coagulopathy or DIC |