Solutions for standardized desensitization protocol (using an example of a target drug dose of 1000 mg)
Solutions for standardized desensitization protocol (using an example of a target drug dose of 1000 mg)
Solution
Volume in mL
Concentration
Dose (mg) in solution
1
250 mL
0.04 mg/mL
10 mg
2
250 mL
0.4 mg/mL
100 mg
3
250 mL
4 mg/mL
1000 mg
The above three solutions are required for the standardized protocol for drug desensitizations for immediate hypersensitivity reactions. Solution 3 is the normal intravenous preparation of the drug as it is usually administered (ie, 1000 mg in 250 mL). Solution 2 is a 10-fold dilution of solution 3, and solution 1 is a 10-fold dilution of solution 2. Note that if the full amount of all three solutions were administered, a total of 1110 mg would be given. To avoid this, only part of solution 3 is infused.