Critical pathways in controlling mycobacterial infection
Critical pathways in controlling mycobacterial infection
Mycobacterial infection induces IL-12 production by monocytes, which stimulates T cells and NK cells to produce IFN-gamma. After binding to its cognate receptor, IFN-gamma activates macrophages to produce TNF-alpha and to kill mycobacteria intracellularly by mechanisms not yet defined. IFN-gamma also drives IL-12 production forward.