INTRODUCTION — Prelabor preterm cervical shortening, particularly before 24 weeks of gestation, is associated with an increased risk for spontaneous preterm birth, which is a major cause of neonatal morbidity and mortality. Detection of a short cervix in the second trimester is useful because providing vaginal progesterone supplementation or performing a cerclage may prolong the gestation compared with expectant management.
This topic will review issues related to sonographic cervical length (CL) screening before 24 weeks for prediction of spontaneous preterm birth in patients with singleton pregnancies and management of those found to have a short cervix. The utility of measurement of CL in twin pregnancies and in the evaluation of suspected preterm labor is reviewed separately. (See "Twin pregnancy: Routine prenatal care", section on 'Screening for short cervical length' and "Preterm labor: Clinical findings, diagnostic evaluation, and initial treatment", section on 'Transvaginal ultrasound examination'.)
RATIONALE FOR MEASURING CERVICAL LENGTH — Cervical shortening is one of the first steps in the processes leading to labor and can precede labor by several weeks. It is most predictive of subsequent spontaneous preterm birth reduction if CL occurs early in pregnancy (before 24 weeks), the degree of reduction is substantial, and/or it occurs in patients with a history of early and/or repeated spontaneous preterm birth [1-8]. Patients with a short cervix can be treated with vaginal progesterone or cerclage, or both, depending on the clinical scenario. Treatment can reduce the risk of preterm birth. (See 'Clinical approach' below.)
Because cervical shortening begins at the internal cervical os and progresses caudally [1,5], a short cervix is often detected on ultrasound examination before it can be appreciated on physical examination. The cause is often unclear. It has been attributed to occult uterine activity, uterine overdistention, congenital or acquired cervical insufficiency, decidual hemorrhage, infection, inflammation, and biological variation.
DIAGNOSIS OF SHORT CERVIX — Before 24 weeks, the diagnosis of a short cervix is based on transvaginal ultrasound cervical length (TVU CL) ≤25 mm (ie, 2nd to 3rd centile), regardless of the patient's obstetric history. This is an appropriate diagnostic threshold because meta-analyses of randomized trials of therapeutic interventions (vaginal progesterone, cerclage) initiated at this threshold in patients with singleton pregnancies report a 30 to 40 percent reduction in preterm birth compared with no intervention [9-11].
Worldwide, there is some variation in the CL threshold that triggers intervention (vaginal progesterone, cerclage) in nonlaboring patients [12]. For example, some clinical guidelines use <15 mm (0.5th centile) and others use <20 mm (1st centile) or <25 mm [13] . The choice reflects a variety of factors, such as the importance placed on sensitivity versus specificity, whether there is a desire to use the threshold from a specific intervention trial, and the patient population. (See 'Clinical approach' below.)
The reported sensitivity of prelabor CL ≤25 mm for preterm birth varies from 6 to 76 percent in the literature [14]. This variation is due in large part to the populations studied and also to methodologic differences among studies. There is, however, general agreement that the overall risk of preterm birth increases as CL decreases below 25 mm and the relationship is strongest when a short cervix is observed before 24 weeks of gestation (sensitivity for preterm birth <35 weeks in singleton pregnancies with length ≤25 mm at ≤25 weeks appears to be 33 percent [15]) or in patients with a prior spontaneous preterm birth, especially before 32 weeks [1-7,16-18]. By comparison, in the third trimester, the relationship between short CL and preterm birth is weak and preterm birth within two weeks of the diagnosis is highly unlikely regardless of the CL [19].
There is no threshold value below which the patient always delivers remote from term. In one study of patients with no measurable CL at 14 to 28 weeks, 25 percent gave birth at ≥32 weeks [20]. In another study of patients with CL ≤25 mm at 24 weeks, 82 percent gave birth at ≥35 weeks; of those with CL ≤13 mm at 24 weeks, 50 percent gave birth at ≥35 weeks [1].
Of note, the diagnosis of short cervix is generally limited to pregnant people. CL measurements performed in nonpregnant females are not useful for predicting spontaneous preterm birth [21].
CLINICAL APPROACH
Overview — The author performs cervical length (CL) screening with transvaginal ultrasound (TVU) by 24 weeks of gestation in all pregnancies, regardless of obstetric history or number of fetuses, as summarized in the algorithm (algorithm 1) and discussed in the following sections of this topic [22]. There is consensus for CL screening in singleton pregnancies less than 24 weeks of gestation at high risk for spontaneous preterm birth (eg, prior spontaneous preterm birth [12]), but the value of using TVU in all pregnancies is controversial [23-26]. Some UpToDate contributors use transabdominal ultrasound for CL screening in pregnancies at average risk of preterm birth, repeating the examination with TVU if the cervix is not well imaged or if it appears to be short (see 'Screening with transvaginal versus a combination of transabdominal and transvaginal ultrasound' below).
A 2019 meta-analysis of randomized trials did not find sufficient evidence to recommend for or against routine CL screening for all pregnant people, because of limitations of the included trials [27]. For example, the threshold for short cervix and timing of the screening examination(s) varied among the trials; there was no standard protocol for management of patients based on CL, and the populations were heterogeneous. Population heterogeneity is important since population characteristics that could affect the performance of the test include the proportion of singleton versus multiple gestations, symptomatic versus asymptomatic patients, intact membranes versus ruptured membranes, prior spontaneous preterm birth versus no prior spontaneous preterm birth, prior indicated preterm birth versus prior spontaneous preterm birth, prior term birth versus no prior term birth, and prior cervical surgery versus no prior cervical surgery [1,7,28-35].
A 2024 meta-analysis of primarily nonrandomized studies found that universal TVU before 24 weeks was associated with a statistically significant reduction in spontaneous preterm birth <32 weeks (0.3 versus 0.4 percent; OR 0.84, 95% CI 0.76-0.94), as well as trends in reduction of spontaneous preterm birth <37 and <34 weeks, compared with no screening [36]. The subset of individuals without a previous history of spontaneous preterm birth showed similar trends, with a statistically significant reduction of spontaneous preterm birth <37 weeks (4.2 versus 4.5 percent; OR 0.88, 95% CI 0.79-0.97). Among screened individuals with a short cervix, approximately 60 percent received vaginal progesterone and 15 percent received a cerclage.
In the largest randomized trial comparing midtrimester TVU CL screening to no screening in over 1300 asymptomatic singleton gestations without prior spontaneous preterm birth, the rate of CL ≤25 mm was 1.9 percent and these patients were treated with vaginal progesterone 200 mg daily and Arabin pessary [37]. Compared with no screening, TVU CL screening resulted in small decreases in preterm birth <37, 34, 32, 28, and 24 weeks; neonatal death; and composite adverse perinatal outcome but none of the reductions were statistically significant.
Positions of some obstetric societies are as follows:
●Society for Maternal-Fetal Medicine (SMFM) – SMFM recommends routine CL screening with TVU between 16 and 24 weeks of gestation for patients with a singleton pregnancy and history of prior spontaneous preterm birth [38]. They consider TVU CL screening reasonable for patients with a singleton pregnancy and no history of prior spontaneous preterm birth but have not recommended routine screening for this population. They recommend not performing routine CL screening for patients with a cervical cerclage, preterm prelabor rupture of membranes, or placenta previa.
●American College of Obstetricians and Gynecologists (ACOG) – In a practice bulletin on preterm birth, ACOG concluded that CL screening with serial TVU is indicated for singleton pregnancies when there is history of a prior spontaneous preterm birth [13]. In the absence of a prior spontaneous preterm birth, ACOG recommended imaging the cervix with either a transabdominal or TVU approach at the 18+0 to 22+6 weeks of gestation fetal anatomy scan.
●International Federation of Gynecology and Obstetrics (FIGO) – FIGO recommends sonographic CL screening in all patients with a singleton pregnancy at 19+0 to 23+6 weeks of gestation using TVU [39].
Specific patient populations
Singleton pregnancies
Patients with NO prior spontaneous preterm birth
●Screening protocol — The author screens these patients for a short cervix with a single TVU examination at approximately 20 weeks (18 to 24 weeks) (algorithm 1) [13,40].
In patients with a short cervix, the rates of spontaneous preterm birth <37, <34, and <32 weeks appear to be similar for both nulliparous and parous patients without a history of spontaneous preterm birth; therefore, the author uses the same screening protocol for both groups. Approximately 1 percent of patients have a short cervix at the author's institution [41]. The rate is slightly higher in nulliparous patients (1.3 to 5.4 percent in one large study [42]) than in parous patients without a prior spontaneous preterm birth [43].
●Management of patients with a short cervix — The author treats patients with singleton gestations, no prior spontaneous preterm birth, and a short cervix with vaginal progesterone [13] and repeats CL measurements every one to two weeks until 24 weeks. The evidence for vaginal progesterone supplementation is reviewed separately. (See "Progesterone supplementation to reduce the risk of spontaneous preterm labor and birth", section on 'Candidates for progesterone supplementation'.)
Other considerations:
•Cerclage – The author suggests that clinicians discuss the available data and its limitations with the patient and make a shared decision regarding placement of a cerclage. This decision may vary depending on whether the CL is ≤10 mm versus ≤15 mm versus ≤20 mm versus ≤25 mm, risk factors for preterm birth, cervical and membrane appearance on speculum examination, cervical findings on digital examination, whether progressive cervical shortening occurs while the patient is being treated with vaginal progesterone, and the patient's values and preferences. Cervical cerclage is not routinely recommended for patients with a short cervix who have not had a prior spontaneous preterm birth since a diagnosis of cervical insufficiency has not been established and many of these patients will have a term or near term birth without surgery. However, available data are limited (discussed below), and practice varies among clinicians.
In a meta-analysis of individual patient data from five randomized trials in which singleton pregnancies without prior spontaneous preterm birth were randomly assigned to cerclage or no cerclage if the cervix was short, cerclage placement did not result in significant reduction in birth <35 weeks (21.9 versus 27.7 percent, relative risk [RR] 0.88, 95% CI 0.63-1.23) [44]. However, planned subgroup analyses suggested a benefit in patients with CL <10 mm (preterm birth <35 weeks: 39.5 versus 58 percent, RR 0.68, 95% CI 0.47-0.98). Observational data support this finding: cerclage placement has been associated with superior neonatal outcome compared with vaginal progesterone in patients with very short (<8 to 10 mm) CLs [45-47]. Based on these data, ISUOG guidelines state that cervical cerclage can be considered in patients whose cervix shortens to <10 mm despite vaginal progesterone treatment [48].
•Pessary – Use of a pessary rather than vaginal progesterone in patients with a short CL has been proposed as an effective, inexpensive, and easy-to-implement method for prolonging pregnancy. Efficacy is not supported by meta-analyses of randomized trials, although some individual trials have reported a reduction in births <34 weeks of gestation. (See "Cervical insufficiency", section on 'Pessary'.)
•Bed rest – Bed rest is not recommended in patients with a short CL. It does not prolong pregnancy, increases the risk for venous thromboembolic events and deconditioning, has negative psychosocial effects, and may increase the risk for preterm birth. (See "Spontaneous preterm birth: Overview of interventions for risk reduction", section on 'Bed rest'.)
Patients with risk factors for but NO prior spontaneous preterm birth
●Screening protocol – For patients with singleton pregnancies with risk factors for spontaneous preterm birth but no prior spontaneous preterm birth, the author screens for a short cervix using a single TVU examination at approximately 20 weeks (18 to 24 weeks). These patients may be nulliparous with risk factors independent of obstetric history (eg, uterine anomaly, conization) or parous with new risk factors (eg, prior cervical conization) that arose after their previous deliveries.
This approach is the same as that for any patient without a previous spontaneous preterm birth. The author does not use a different screening protocol for patients with risk factors because their pregnancy outcome needs to be established before committing them to serial CL surveillance and possibly a cervical procedure (cerclage) that may be unnecessary. Although a minority of these patients develop cervical insufficiency, most do not; therefore, he believes the pregnancy course and outcome need to be evaluated before making this diagnosis.
●Management of patients with a short cervix – The author manages patients with risk factors for but no previous preterm birth who have a short cervix in the same way as described above for patients without a history of preterm birth who develop a short cervix: vaginal progesterone for most patients but consideration of cerclage in selected patients. (See 'Patients with NO prior spontaneous preterm birth' above.)
Patients WITH a prior spontaneous preterm singleton birth
●Screening protocol – For patients with a singleton pregnancy and a history of prior spontaneous preterm singleton birth, the author of this topic begins TVU CL screening at 14 to 16 weeks of gestation (the earlier the prior spontaneous preterm birth, the earlier the screening) and performs serial examinations as shown in the algorithm (algorithm 1). Serial screening was more effective than a single screen in large trials of screening in this population [7,49].
●Management of patients with a short cervix – Patients with a prior spontaneous preterm birth are at high risk for recurrence. The author of this topic starts these patients on vaginal progesterone at 16 weeks, 200 mg every evening, based on the results of two meta-analyses, before adjustment for trial quality [50,51]. However, this remains a controversial area. (See "Progesterone supplementation to reduce the risk of spontaneous preterm labor and birth", section on 'Singleton pregnancy with prior preterm birth'.)
If a short cervix is identified on ultrasound, he makes the diagnosis of cervical insufficiency and offers cerclage. The rationale/evidence for this approach and management of these pregnancies are discussed in detail separately. (See "Cervical insufficiency", section on 'Ultrasound-based diagnosis of cervical insufficiency' and "Cervical insufficiency", section on 'Ultrasound-based cervical insufficiency'.)
Patients WITH a prior spontaneous preterm TWIN birth — The best approach to patients with a singleton pregnancy and a prior spontaneous twin birth is controversial. Some studies have reported that a prior spontaneous twin birth is associated with an increased risk of spontaneous preterm birth in the subsequent singleton pregnancy [52-54]. The increased risk appears to be limited to previous twin births <34 weeks [52,54].
The author offers vaginal progesterone (starting at 16 weeks, 200 mg every evening) to patients with a singleton pregnancy and prior spontaneous preterm birth of a twin pregnancy, based on the results of two meta-analyses, before adjustment for trial quality [50,51]. However, use of vaginal progesterone to improve pregnancy outcome in patients with a previous preterm birth remains a controversial area. (See "Progesterone supplementation to reduce the risk of spontaneous preterm labor and birth", section on 'Singleton pregnancy with prior preterm birth'.)
●Screening protocol
•Prior twin spontaneous late preterm birth (≥34 weeks) – The author screens for a short cervix with a single TVU examination at approximately 20 weeks (18 to 24 weeks) as in singleton pregnancies with no prior preterm birth (algorithm 1).
•Prior twin spontaneous early preterm birth (<34 weeks) – The author begins TVU CL screening at 14 to 16 weeks of gestation (the earlier the prior spontaneous preterm birth, the earlier the screening) and performs serial examinations as in singleton pregnancies with a prior preterm birth (algorithm 1).
●Management of patients with a short cervix
•Prior twin spontaneous late preterm birth (≥34 weeks) – The author manages these patients similar to those with singleton gestations, no prior spontaneous preterm births, and a short cervix. (See 'Patients with NO prior spontaneous preterm birth' above.)
•Prior twin spontaneous early preterm birth (<34 weeks) – The author makes a diagnosis of cervical insufficiency and offers cerclage. The rationale/evidence for this approach and management of these pregnancies are discussed in detail separately. (See "Cervical insufficiency", section on 'Ultrasound-based cervical insufficiency'.)
Twin pregnancies — The screening protocol for patients with twins and management of those with a short cervix is reviewed separately. (See "Twin pregnancy: Management of pregnancy complications", section on 'Approach to patients with a short cervix'.)
PROCEDURE FOR SONOGRAPHIC MEASUREMENT OF CERVICAL LENGTH
Basis for timing the first and last screening test — Cervical length (CL) is affected by gestational age but not significantly affected by parity, race/ethnicity, or maternal height [1-3,55-59].
Reproducible measurement of CL usually becomes possible at approximately 14 weeks of gestation and is consistently possible by 16 to 18 weeks when the cervix normally becomes distinct from the lower uterine segment [40]. CL measurements before 14 weeks of gestation have limited clinical value [40,60]. However, in some particularly high-risk pregnancies, such as those with prior second-trimester losses and/or large (or multiple) excisional biopsies, cervical shortening has been seen as early as 10 to 13 weeks of gestation and was associated with a high risk of second-trimester loss [40].
Normally, CL is stable between 14 and 28 weeks of gestation and is described by a bell-shaped curve [1,61]. Approximately 90 percent of nulliparous patients with singleton pregnancies have CL >30 mm between 16 and 22 weeks of gestation [42]. The median CL is 40 mm before 22 weeks, 35 mm at 22 to 32 weeks, and 30 mm after 32 weeks.
Screening is discontinued at 24 weeks because intervention trials have begun treatment by 24 weeks of gestation. After 30 weeks, CL measurement is generally not useful for predicting spontaneous preterm birth because, as noted above, the cervix physiologically starts to shorten at this time, even in patients destined to deliver at term.
Screening with transvaginal versus a combination of transabdominal and transvaginal ultrasound — The author performs transvaginal ultrasound (TVU) CL screening in all pregnancies because TVU cervical measurements are more reproducible and reliable than those obtained by transabdominal ultrasound (TAUS) and more sensitive for prediction of spontaneous preterm birth [62-69]. It is also important to note that all randomized trials supporting the efficacy of treatment of patients with a short cervix used TVU to measure CL [28,49,61,70-74].
Another approach used by some clinicians is to measure CL by TVU routinely in patients with risk factors for spontaneous preterm birth. However, in patients thought to be at low risk for spontaneous preterm birth, CL is measured transabdominally (TAUS) during the routine second-trimester sonographic fetal anatomic survey: If the TAUS cervix is short or is not adequately seen, then a TVU examination is performed for a definitive measurement; if the TAUS cervix is clearly imaged and long, then TVU may be avoided [75]. Using this approach, approximately 60 percent of patients need both a TAUS and a TVU to assure that >95 percent of patients with a short cervix on TVU are detected [66]. As a result, this approach is neither time-saving nor cost-effective [76].
The poorer performance of TAUS has been attributed to multiple factors, including (1) the bladder often needs to be filled to obtain a good image, resulting in elongation of the cervix and masking of any funneling of the internal os; (2) fetal parts can obscure the cervix, especially after 20 weeks; (3) the distance from the probe to the cervix results in degraded image quality; and (4) obesity and manual pressure interfere with the image [69].
Transvaginal ultrasound technique — The basic steps for the TVU technique are:
●The patient should empty her bladder prior to the examination.
●Ultrasound gel is placed on a transvaginal probe before covering it with a specialized probe cover or condom, and then more ultrasound gel is placed on top of the cover. If the membranes are ruptured, both the cover and the gel should be sterile.
●With the real-time image in view, the transducer is gently inserted into the anterior fornix until the cervix is visualized while avoiding excessive pressure on the anterior cervical lip. The image of the cervix is enlarged to fill at least one-half of the ultrasound screen and oriented so cephalad is to the left of the screen. Fetal membranes in the cervical canal or beyond the cervix should be noted, if present.
●The amniotic fluid in the lower uterine segment is assessed and then the lowest edge of the empty maternal bladder. The internal os is then located, often just below this edge.
●The appropriate sagittal long-axis view for measuring CL includes the usually V-shaped notch at the internal os, the triangular area of echodensity at the external os, and the endocervical canal, which appears as a faint line of echodensity or echolucency between the two (figure 1). Excess pressure on the cervix can artificially increase its apparent length. This can be avoided by first obtaining an apparently satisfactory image, withdrawing the probe until the image blurs, and then reapplying only enough pressure to restore the image (image 1).
●CL is represented by the line made by the interface of the mucosal surfaces (the closed portion of the cervix). It is usually the distance between calipers placed at the notches made by the internal os and external os. If the internal os is open (image 2), CL is measured from the tip of the funnel to the external os (figure 1). CL should only be determined from images in which the lowermost edge of the empty maternal bladder and the internal os and external os are visible and when the anterior and posterior lips of the cervix are of approximately equal thickness. If the cervix appears asymmetric (thin anteriorly and thicker posteriorly), this suggests excessive probe pressure.
●At times, the cervical canal is curved. In these cases, the length of the cervix can be measured in either of two ways:
•The length of a single, straight line from the internal to external os can be measured.
•The sum of two separate, straight lines joined at an angle along the curved length of cervix is determined: This sum is used for the CL if the distance between the angle and a straight line from the internal to external os is >5 mm (image 3) as it may provide a more accurate measurement [7].
We avoid tracing the cervical canal because it introduces unpredictable operator variation. A curved cervix usually means a long cervix and thus a low risk for spontaneous preterm birth, while a short cervix is usually straight.
●When three measurements have been obtained that satisfy measurement criteria and vary by less than 10 percent, the shortest of these is chosen and recorded as the "shortest best." Choosing the shortest of three excellent images reduces interobserver variation. Determining the best measurement by image quality is less accurate because this introduces an unpredictable variable.
●Moderate to firm manual transabdominal pressure applied across the fundus in the direction of the uterine axis for 15 seconds [77] can aid the examination by revealing a "dynamic" cervix (ie, the development of short CL in a cervix seemingly initially of normal length) [7,78]. It is important to allow at least five minutes for the total examination and a couple of minutes between the gentle application of fundal pressure and recording the presence of a short cervix as it takes time for development of dynamic and/or "transfundal pressure elicited" changes in the cervix [79].
If a short (or shorter) CL is seen after application of fundal pressure, the length of the residual closed portion of the cervix is taken three times, with the shortest length recorded in millimeters as the best estimate of the true length of the cervix. This length best correlates with duration of pregnancy. Only one measurement should be reported: the shortest best CL (mm) of all measurements taken.
With proper technique, intra- and interobserver variation in CL is <10 percent.
Pitfalls in measuring cervical length — The following pitfalls can lead to suboptimal measurement of CL, typically resulting in overestimation:
●Excessive pressure – Placing excessive pressure on the cervix during the examination is a common mistake in performing TVU. This creates an artificially longer cervix due to compression of the anterior cervical lip and lower uterine segment. As discussed above, this may be avoided by withdrawing the probe when the internal os and external os are visualized until slight blurring occurs, and then the probe is inserted slightly until a clear image returns. The anterior and posterior lips of the cervix should be of approximately equal thickness (figure 1).
●Not allowing enough time to view dynamic changes – Measuring CL too quickly is common and can result in an inaccurate measurement. It is important to allow adequate time (approximately five minutes) for any effects of transient pressure on the cervix to resolve.
●Uterine contractions – TVU CL is optimally obtained when a lower uterine segment contraction is not seen. Contractions during the examination can cause a false impression of a long cervix and are the most frequent pitfall in TVU CL measurement.
TVU CL measurement soon after bladder voiding is often associated with a contraction (16 to 43 percent of scans [80,81]). In these cases, the sonographer can monitor CL until the contraction resolves or complete other aspects of the fetal ultrasound examination and then check CL. If the contraction persists even after waiting 20 minutes or more, the TVU CL should not be reported because it may not be accurate and patient should be re-examined on another day [81]. Contraction of the lower uterine segment can mimic funneling with a normal residual CL and thus can mask short CL, particularly in individuals with a prior spontaneous preterm birth [80,81].
●Underdevelopment of the lower uterine segment – As discussed above, before 14 weeks, it is more difficult to differentiate between the lower uterine segment and true cervix as the pregnancy has not yet expanded to the whole uterus. Placenta previa may create this same problem, resulting in an artificially increased CL.
If the lower uterine segment is underdeveloped, it can be difficult to identify the true internal os, and some myometrium may be included in the CL measurement. This should be suspected when the cervix appears longer than 50 mm or the internal os is cephalad above the bladder reflection [16]. A difference in echotexture between myometrium and true cervical stroma often can be appreciated during real-time scanning and provides a means for differentiating between the two structures.
●Prior cervical surgery – Prior cervical surgery may alter the appearance of the cervix, making the identification of measurement landmarks difficult.
●Air bubbles – Hasty placement of lubricant into the transducer cover may generate small air bubbles that create a poor image.
Other cervical findings — During the ultrasound examination, additional findings associated with spontaneous preterm birth may be noted.
●Change in length over time – In patients diagnosed with a short cervix, a stable or longer CL at a subsequent examination is associated with a lower risk for spontaneous preterm birth than initially predicted, while a shorter CL increases the risk of spontaneous preterm birth [82-84].
●Separation of the membranes from the decidua and debris/sludge (hyperechoic matter in the amniotic fluid (image 4)) close to the internal os suggest subclinical infection and an increased risk of spontaneous preterm birth [85-88]. The composition of the debris is unclear; it may be a blood clot, meconium, vernix, or cellular material related to infection/inflammation [89].
●Funneling is the protrusion of the amniotic membranes into the cervical canal. Funneling has been variably defined according to the depth of protrusion [1] and/or the ratio of the funnel depth to the length of funnel plus the remaining closed cervix [78]. As the cervix effaces, the relationship between the lower uterine segment and the axis of the cervical canal also changes and is described according to the shape of the letters "T," "Y," "V," and "U" (mnemonic: Trust Your Vaginal Ultrasound) (figure 2) [58]. "T" represents the normal relationship of the area where the endocervical canal meets the uterine cavity, whereas "U" represents almost complete effacement and signifies the highest risk for spontaneous preterm birth. Representative endovaginal ultrasound images that display these changes are shown in the following ultrasounds (image 5A-C).
The length of the funnel is often uncertain because landmarks, such as the shoulder of the internal os, may not be distinct; therefore, the author does not measure funnel length or use it for clinical management. In fact, while funneling is associated with a short cervix, it is not an independent predictor of preterm labor risk when the closed length of the cervical canal is considered [7,78]. As discussed above, when funneling is present with a normal residual CL, it is usually related to a contraction of the lower uterine segment and has little to no clinical significance.
●Assessment of cervical tissue density, cervical axis relative to the uterine corpus, and other cervical characteristics does not significantly improve predictive value for spontaneous preterm birth over CL alone [7,78,90].
SOCIETY GUIDELINE LINKS — Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Preterm labor and birth".)
SUMMARY AND RECOMMENDATIONS
●Significance of short cervical length – A decrease in cervical length (CL) to ≤25 mm before 24 weeks is predictive of spontaneous preterm birth, and this risk increases as CL decreases. By contrast, a gradual decline in CL after 32 weeks can be normal and not predictive of spontaneous preterm birth. (See 'Rationale for measuring cervical length' above.)
●Screening – We suggest routine transvaginal ultrasound (TVU) screening for short cervix (Grade 2B) since appropriate interventions to reduce the risk of spontaneous preterm birth are available. The following algorithm summarizes our approach (algorithm 1). (See 'Clinical approach' above.)
●Procedure for measuring cervical length – CL is measured by determining the length of closed cervix between the internal os and external os on TVU. It should only be determined from images in which the lowermost edge of the empty maternal bladder and the internal os and external os are visible and when the anterior and posterior lips of the cervix are of equal thickness (figure 1). (See 'Procedure for sonographic measurement of cervical length' above.)
●Diagnosis of short cervical length – The diagnosis of a short cervix is based on TVU CL ≤25 mm before 24 weeks, regardless of the population (eg, prior preterm birth, no prior preterm birth, twin gestation). (See 'Diagnosis of short cervix' above and 'Procedure for sonographic measurement of cervical length' above.)
●Management
•Patients with a singleton gestation, NO PRIOR spontaneous preterm birth, and a short cervix are offered vaginal progesterone to reduce the chances of preterm birth. Placement of a cerclage may be helpful in those with a very short cervix (TVU CL <10 mm). (See "Progesterone supplementation to reduce the risk of spontaneous preterm labor and birth", section on 'Candidates for progesterone supplementation' and 'Patients with NO prior spontaneous preterm birth' above.)
Patients with a singleton gestation, risk factors for but NO PRIOR spontaneous preterm birth, and a short cervix are managed similarly. (See 'Patients with risk factors for but NO prior spontaneous preterm birth' above.)
•Patients with a singleton gestation, a PRIOR spontaneous preterm SINGLETON birth, and a short cervix – The author of this topic offers patients with a singleton gestation and a prior spontaneous preterm birth vaginal progesterone at 16 weeks, based on the results of two meta-analyses, before adjustment for trial quality; however, this remains a controversial area. If a short cervix is identified on ultrasound, he makes the diagnosis of cervical insufficiency and offers cerclage. (See "Progesterone supplementation to reduce the risk of spontaneous preterm labor and birth", section on 'Singleton pregnancy with prior preterm birth'.)
•Patients with a singleton gestation, a PRIOR spontaneous preterm TWIN birth, and a short cervix – The author of this topic offers patients with a singleton gestation and a prior spontaneous preterm twin birth vaginal progesterone at 16 weeks, based on the results of two meta-analyses, before adjustment for trial quality; however, this remains a controversial area. Those who develop a short cervix are managed according to whether the prior twin birth occurred before or after 34 weeks. (See 'Patients WITH a prior spontaneous preterm TWIN birth' above.)
8 : Universal cervical length screening for preterm birth is not useful after 24 weeks of gestation.
31 : Cervical length for prediction of preterm birth in women with multiple prior induced abortions.
53 : Recurrence risk of preterm birth in subsequent singleton pregnancy after preterm twin delivery.
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