Anesthesia, ocular: Ophthalmic gel: Children and Adolescents: Apply 2 drops to ocular surface in area where procedure to occur; may reapply to maintain effect.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling
(For additional information see "Lidocaine (ophthalmic): Drug information")
Anesthesia, ocular: Apply 2 drops to ocular surface in area where procedure will occur; may reapply to maintain effect.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Central Nervous System: Localized burning
Ophthalmic: Conjunctival hyperemia, diplopia, epithelial keratopathy, visual disturbance
There are no contraindications listed in the manufacturer's labeling.
Concerns related to adverse effects:
• Corneal ulceration: Prolonged use may cause permanent corneal ulceration and/or opacification with loss of vision.
Dosage form specific issues:
• Appropriate use: For ophthalmic use only; not for injection.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Gel, Ophthalmic, as hydrochloride [preservative free]:
Akten: 3.5% (1 mL)
No
Gel (Akten Ophthalmic)
3.5% (per mL): $28.03
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For topical ophthalmic use only; not for injection. For single use only; discard unused portion.
Ophthalmic: For topical ophthalmic use only; not for injection. For administration by health care provider; not for patient self-administration. For single use only; discard unused portion.
Store in original container at 15°C to 25°C (59°F to 77°F). Protect from light. Discard after use.
Local anesthetic to ocular surface during ophthalmic procedures (FDA approved in pediatric patients [age not specified] and adults)
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program
Methemoglobinemia Associated Agents: May enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. Risk C: Monitor therapy
Adverse events were not observed in animal reproduction studies. Although systemic exposure is not expected following application of the ophthalmic gel, cumulative exposure from all routes of administration should be considered.
Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions, which results in inhibition of depolarization with resultant blockade of conduction.
Onset of action: 20 seconds to 5 minutes (median: 40 seconds)
Duration: 5 to 30 minutes (median: 15 minutes)
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