Symptoms of juvenile primary fibromyalgia syndrome (JPFS) and related comorbid conditions

Symptom of JPFS	Related comorbid conditions
Chronic pain	Pediatric generalized hypermobility spectrum disorder Temporomandibular joint disorder
Headaches	Headache disorders (eg, tension-type headaches, migraine headaches) Secondary headache disorders (eg, medication overuse headache)
Fatigue	Myalgic encephalomyelitis/chronic fatigue syndrome Long COVID
Sleep disturbances	Primary sleep disorders (eg, periodic limb movement disorder, restless legs syndrome)
Anxious or depressed mood	Mood disorders (eg, anxiety, depression)
Dizziness	Orthostatic intolerance Postural tachycardia syndrome
Gastrointestinal disturbances	Irritable bowel syndrome
Genitourinary pain	Interstitial cystitis/bladder pain syndrome Endometriosis Vulvodynia

To be used with UpToDate content on the clinical manifestations and diagnosis of fibromyalgia in children and adolescents.

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