Return To The Previous Page
Buy a Package
Number Of Visible Items Remaining : 3 Item

Characteristics of gestational trophoblastic disease

Characteristics of gestational trophoblastic disease
  Partial mole Complete mole
Fetus
  • Present*
  • Syndactyly involving digits 3 and 4, especially of the hand*
  • Absent*
Cytotrophoblasts
  • Mild atypia and proliferation*
  • Often atypical, significant and focally extreme proliferation*
Syncytiotrophoblasts
  • Mild atypia and proliferation*
Implantation site extravillous (intermediate) trophoblasts
  • Infrequently atypical*
Chorionic membranous extravillous (intermediate) trophoblasts
  • Chorion and amnion usually present*
  • Absent
Chorionic villi
  • Biphasic – having normal and enlarged, irregularly shaped populations with scattered cavitated villi*
  • "Classic" lesions have diffusely enlarged and frequent villous cavitation*
  • Early lesions have myxoid basophilic (blue) stroma and deep, narrow inclusion of surface trophoblast layer*
Biological potential
  • Mostly benign, even when hCG persists
  • Rarely associated with choriocarcinoma, PSTT, or ETT
  • Invasive or metastatic in approximately 20% of cases
Differential diagnosis
  • Aneuploid gestation (eg, trisomy 11, 13, 18, or 21)
  • Complete hydatidiform mole plus normal co-twin
  • Mesenchymal dysplasia and Beckwith-Wiedemann syndrome (p57 abnormalities cause by different mechanism)
  • Hydropic (degenerating) abortus
  • Partial hydatidiform mole
  • Unusual complete hydatidiform mole-like chimeric/mosaic gestations
Typical genetics
  • Diandric triploid gestations (69,XXX, 69,XXY, rarely 69,XYY) with 2 sets of paternal chromosomes
  • 46,XX karyotype, with all chromosomes of paternal origin
  • Rarely, familial and biparental inheritance can occur due to germline mutations of NRLP7, KHDC3L, or PADI6
Key marker status
  • p57 immunostaining retained
  • p57 immunostaining is absent in villous cytotrophoblasts and stromal cells

ETT: epithelioid trophoblastic tumor; hCG: human chorionic gonadotropin; PSTT: placental site trophoblastic tumor.

* Denotes features that are typically present.
Graphic 144913 Version 1.0

Do you want to add Medilib to your home screen?