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2022 ACR/EULAR classification criteria for EGPA

2022 ACR/EULAR classification criteria for EGPA
Considerations when applying these criteria
  • These classification criteria should be applied to classify a patient as having eosinophilic granulomatosis with polyangiitis when a diagnosis of small- or medium-vessel vasculitis has been made
  • Alternate diagnoses mimicking vasculitis should be excluded prior to applying the criteria
Clinical criteria
Obstructive airway disease +3
Nasal polyps +3
Mononeuritis multiplex +1
Laboratory and biopsy criteria
Blood eosinophil count ≥1 × 109/liter +5
Extravascular eosinophilic-predominant inflammation on biopsy +2
Positive test for cytoplasmic antineutrophil cytoplasmic antibodies (cANCA) or antiproteinase 3 (anti-PR3) antibodies –3
Hematuria –1
Sum the scores for 7 items, if present. A score of ≥6 is needed for classification of eosinophilic granulomatosis with polyangiitis.
2022 American College of Rheumatology (ACR)/European Alliance of Associations (EULAR) for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis (EGPA). This classification scheme is used to distinguish EGPA from other vasculitides in patients with known small or medium-vessel vasculitis.
From: Grayson PC, Ponte C, Suppiah R, et al. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for eosinophilic granulomatosis with polyangiitis. Ann Rheum Dis 2022; 81:309-314. Copyright © 2022 The Authors (or their employers). Reproduced with permission from BMJ Publishing Group Ltd.
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