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Medications that may affect kidney function or kidney function estimates in people with HIV

Medications that may affect kidney function or kidney function estimates in people with HIV
Mechanism Medication
Reduced tubular secretion of creatinine
  • Integrase inhibitors: dolutegravir, elvitegravir, bictegravir, cabotegravir
  • Cobicistat
  • Rilpivirine
  • Trimethoprim
Acute interstitial nephritis
  • Atazanavir
  • Nonsteroidal antiinflammatory drugs (NSAIDs)
  • Proton pump inhibitors
  • Rifampin
  • Trimethoprim-sulfamethoxazole
Proximal tubulopathy
  • Tenofovir disoproxil fumarate
Acute tubular injury
  • Aminoglycosides
  • Amphotericin B
  • Intravenous acyclovir
  • Cidofovir
  • Foscarnet
  • Pentamidine
Crystal-induced acute kidney injury
  • Intravenous acyclovir
  • Sulfamethoxazole
Chronic kidney disease
  • Tenofovir disoproxil fumarate
  • Atazanavir
  • Ritonavir-boosted lopinavir
HIV: human immunodeficiency virus.
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