Disease course per age at onset group. Age at onset of vanishing white matter (VWM) and age at times of loss of walking without support, full wheelchair dependency, start of tube feeding, and death among 291 patients are shown. The horizontal arrows range from birth to the longest follow-up in the respective age at onset group. The numbers below the horizontal arrows indicate the median age (years) at the respective event as estimated with the use of Kaplan-Meier curves.
From: Hamilton EMC, van der Lei HDW, Vermeulen G, et al. Natural history of vanishing white matter. Ann Neurol 2018; 84:274.
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