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Proteins that undergo vitamin K-dependent gamma-glutamyl carboxylation

Proteins that undergo vitamin K-dependent gamma-glutamyl carboxylation
Coagulation factors
  • Factor II (prothrombin)
  • Factor VII
  • Factor IX
  • Factor X
Natural anticoagulants
  • Protein C
  • Protein S
  • Protein Z
Proteins of mineralized, connective, or vascular tissues
  • Osteocalcin (bone Gla protein)
  • Matrix Gla protein
  • Gla-rich protein (GRP)
Other
  • Gas6
  • Vitamin K-dependent single pass integral membrane proteins
  • Endoplasmic reticulum Gla protein
Refer to UpToDate for details of Gla synthesis and the functions of Gla-containing proteins.
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