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Drugs and toxins that can cause hypophosphatemia

Drugs and toxins that can cause hypophosphatemia
Acetazolamide
Antacids (aluminum- and magnesium-based)
Antiretroviral agents:
  • Tenofovir
  • Adefovir
  • Cidofovir
Bisphosphonates
Chemotherapeutic agents:
  • Chimeric antigen receptor modified (CAR)-T cell therapy (eg, tisagenlecleucel, axicabtagene ciloleucel)
  • Cisplatin
  • Ifosfamide
  • Tyrosine kinase inhibitors (eg, imatinib)
  • Vascular endothelial growth factor (VEGF) inhibitors (eg, sorafenib)
Denosumab
Heavy metals (cadmium, lead, arsenic)
Insulin
Intravenous iron (specifically, ferric carboxymaltose)
Mechanistic (mammalian) target of rapamycin (mTOR) inhibitors (eg, temsirolimus)
Niacin
Phosphate binders
Valproate
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