Patients who are medically fit and eligible for cisplatin-based therapy meet all of the criteria below: |
ECOG performance status <2 or a Karnofsky performance status >70% |
Creatinine clearance ≥60 mL/min |
No significant hearing loss (measured at audiometry of 25 dB at 2 contiguous frequencies) |
Grade <2 peripheral neuropathy (ie, sensory alteration or paresthesia, including tingling, but not interfering with activities of daily living) |
No clinical evidence of NYHA class III or greater heart failure |
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