Endometrial carcinoma is surgically staged; the staging system is presented in detail separately.
Patients with local/regional spread, spread to the bladder or intestinal mucosa, or distant metastases are discussed elsewhere.LVSI: lymphovascular space invasion.
* Nonendometrioid tumors include serous, clear cell, carcinosarcoma, mixed, undifferentiated, and mesonephric-like carcinomas.
¶ Definitions of grade:Δ Molecular factors (eg, DNA polymerase epsilon mutated [POLEmut], mismatch repair deficient [MMRd], no specific molecular profile [NSMP], p53 abnormal [p53abn]), if obtained, can be used to up-stage or down-stage early endometrial carcinomas and may help inform prognosis and guide treatment decisions.
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