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Staging evaluation and initial management of clinically evident lymph nodes in locoregional Merkel cell carcinoma

Staging evaluation and initial management of clinically evident lymph nodes in locoregional Merkel cell carcinoma
The staging evaluation and initial management of clinically evident lymph nodes in locoregional MCC is presented here. Clinically evident lymph nodes are regional lymph nodes detected on physical exam or imaging that are suspected to have disease involvement. All patients should undergo staging evaluation of the lymph nodes prior to or in conjunction with definitive treatment of the primary tumor. After completion of all therapy, all patients should be offered routine posttreatment surveillance. Refer to UpToDate content on staging, treatment, and surveillance of locoregional MCC.

MCC: Merkel cell carcinoma; SLNB: sentinel lymph node biopsy; RT: radiation therapy; FNA: fine needle aspiration.

* Reasons for false-negative biopsy results include wide local excision of the primary tumor prior to biopsy; prior history of lymph node excision or nodal melanoma; multiple lymph node basins (eg, MCC of the head and neck or midline-trunk); or technical issues with tissue processing.

¶ Definitive RT is delivery of radiation as the sole modality for local disease control.

Δ For details on routine post-treatment surveillance, refer to UpToDate content on staging, treatment, and surveillance of locoregional MCC.
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