Oxygenation | CO2 removal |
Blood flow rate (L/minute; ie, blood flow entering membrane from the pump) | Sweep gas flow rate (L/minute; ie, fresh gas [mix of oxygen and air] flowing into the membrane) |
Blood flow:cardiac output ratio* | Blood flow rate (L/minute) (ie, blood flow entering membrane from the pump) CO2 removal will be more dependent on blood flow rate at lower flow rates (eg, <3 L/minute) |
Diffusion properties of the membrane¶ Membrane lung surface area and design | Diffusion properties of the membrane¶ Membrane lung surface area and design |
Native lung gas exchangeΔ | Native lung gas exchangeΔ |
Degree of recirculation◊ | Partial pressure of CO2 entering the membrane lung |
Dual circulation/competitive flow phenomenon§ |
ECLS: extracorporeal life support; V-V: venovenous; ECMO: extracorporeal membrane oxygenation; V-A: venoarterial.
* Applies only to V-V ECMO.
¶ Different membrane materials have different diffusion properties and diffusion can be affected by processes such as thrombus.
Δ This may vary and represent that achieved through mechanical ventilation or that achieved with spontaneous ventilation.
◊ Applies only to V-V ECMO, particularly when using a 2-site approach.
§ Applies to V-A ECMO only (refer to UpToDate topics on extracorporeal membrane oxygenation).Do you want to add Medilib to your home screen?