ACKR1 genotype/Duffy phenotype | ||
Duffy-null* | Non-Duffy-null | |
Hemolytic transfusion reactions (HTRs)¶ |
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Hemolytic disease of the fetus and newborn (HDFN)Δ |
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ANC normal range |
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Risk of infections |
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Drug dosing | Drug dosing should not be altered based on baseline ANC (consider Duffy-null specific reference ranges). | |
Relatives | May benefit from knowing their status for reasons mentioned above. |
ACKR1: atypical chemokine receptor 1; HTR: hemolytic transfusion reaction; RBC: red blood cell; HDFN: hemolytic disease of the fetus and newborn; Fy: Duffy antigen; ANC: absolute neutrophil count.
* Other designations for Duffy-null include:¶ Pretransfusion testing is routinely used to avoid antigens implicated in hemolytic transfusion reactions.
Δ Maternal antibody screen is routinely performed during pregnancy to identify risk for HDFN and need for additional testing and monitoring. Only anti-Fya has been associated with HDFN.Do you want to add Medilib to your home screen?