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Medullary thyroid cancer: Findings on surgical histology

Medullary thyroid cancer: Findings on surgical histology

(A) H&E low power: Medullary thyroid carcinoma with the typical solid nested architecture.

(B) H&E high power: Medullary thyroid carcinoma with the typical solid nested architecture. The tumor cells have neuroendocrine type nuclei and can be plasmacytoid (center of the nest).

(C) Calcitonin immunostain: In almost all cases, the tumor is diffusely positive for calcitonin.
H&E: hematoxylin and eosin stain.
Courtesy of Ronald A Ghossein, MD.
Graphic 140063 Version 1.0