Version October 2024
AFP: alpha-fetoprotein; hCG: human chorionic gonadotropin; MRI: magnetic resonance imaging; CSF: cerebrospinal fluid; SOC: standard of care; CSI: craniospinal irradiation; WVI: whole-ventricular irradiation; WVSCI: whole-ventricular and spinal cord irradiation; RT: radiation therapy.
* International consensus is lacking on the magnitude of hCG elevation that reliably distinguishes a germinoma from an NGGCT.
¶ The choice between RT alone and neoadjuvant chemotherapy plus response-adapted RT in germinoma is individualized; combination therapy is favored in younger patients. Refer to UpToDate topic on intracranial GCTs for more details.
Δ Mature teratoma has normal AFP and hCG.
◊ Optimal treatment for patients who have evidence of residual disease after maximal safe resection is not known; consider focal adjuvant RT.Do you want to add Medilib to your home screen?
