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Preferred antihypertensive drugs available as single-pill combinations: Adult dosing*

Preferred antihypertensive drugs available as single-pill combinations: Adult dosing*
Combination Once-daily oral dose
Low dose Moderate dose High dose
Angiotensin-converting enzyme inhibitor and thiazide diuretic
Benazepril-hydrochlorothiazide 5 mg/6.25 mg 10 mg/12.5 mg or 20 mg/12.5 mg 20 mg/25 mg
Enalapril-hydrochlorothiazide 5 mg/12.5 mg 10 mg/25 mg Not available
Fosinopril-hydrochlorothiazide 10 mg/12.5 mg 20 mg/12.5 mg 40 mg/25 mg
Lisinopril-hydrochlorothiazide 10 mg/12.5 mg 20 mg/12.5 mg or 20 mg/25 mg 40 mg/25 mg
Perindopril-indapamide
(United States: Not available)		 2 mg/0.625 mg 4 mg/1.25 mg 8 mg/2.5 mg
Quinapril-hydrochlorothiazide 10 mg/12.5 mg 20 mg/12.5 mg 20 mg/12.5 mg
Ramipril-hydrochlorothiazide
(United States: Not available)		 2.5 mg/12.5 mg 5 mg/12.5 mg or 5 mg/25 mg 10 mg/12.5 mg or 10 mg/25 mg
Angiotensin-converting enzyme inhibitor and dihydropyridine calcium channel blocker
Amlodipine-benazepril 2.5 mg/10 mg or 5 mg/10 mg 5 mg/20 mg 10 mg/20 mg or 10 mg/40 mg
Perindopril-amlodipine 3.5 mg/2.5 mg 7 mg/5 mg 14 mg/10 mg
Ramipril-amlodipine
(United States: Not available)		 2.5 mg/2.5 mg 5 mg/5 mg or 10 mg/5 mg 5 mg/10 mg or 10 mg/10 mg
Angiotensin II receptor blocker and thiazide diuretic
Azilsartan-chlorthalidone 40 mg/12.5 mg 40 mg/25 mg 40 mg/25 mg
Candesartan-hydrochlorothiazide 16 mg/12.5 mg 32 mg/12.5 mg 32 mg/25 mg
Irbesartan-hydrochlorothiazide 150 mg/12.5 mg 300 mg/12.5 mg 300 mg/25 mg
Losartan-hydrochlorothiazide 50 mg/12.5 mg 100 mg/12.5 mg 100 mg/25 mg
Olmesartan-hydrochlorothiazide 20 mg/12.5 mg 40 mg/12.5 mg 40 mg/25 mg
Telmisartan-hydrochlorothiazide 40 mg/12.5 mg 80 mg/12.5 mg 80 mg/25 mg
Valsartan-hydrochlorothiazide 80 mg/12.5 mg 160 mg/12.5 mg or 160 mg/25 mg 320 mg/12.5 mg or 320 mg/25 mg
Angiotensin II receptor blocker and dihydropyridine calcium channel blocker
Amlodipine-olmesartan 5 mg/20 mg 5 mg/40 mg or 10 mg/20 mg 10 mg/40 mg
Amlodipine-valsartan 5 mg/160 mg 5 mg/320 mg or 10 mg/160 mg 10 mg/320 mg
Telmisartan-amlodipine 40 mg/5 mg 40 mg/10 mg or 80 mg/5 mg 80 mg/10 mg
Angiotensin II receptor blocker, calcium channel blocker, and thiazide diuretic
Amlodipine-valsartan-hydrochlorothiazide 5 mg/160 mg/12.5 mg 5 mg/160 mg/25 mg 10 mg/160 mg/12.5 mg or 10 mg/160 mg/25 mg or 10 mg/320 mg/25 mg
Olmesartan-amlodipine-hydrochlorothiazide 20 mg/5 mg/12.5 mg 40 mg/5 mg/12.5 mg or 40 mg/5 mg/25 mg 40 mg/10 mg/12.5 mg or 40 mg/10 mg/25 mg
Angiotensin-converting enzyme inhibitors are commonly known as ACE inhibitors. Angiotensin II receptor blockers are commonly known as ARBs. A low-dose combination product is often prescribed as initial therapy in patients whose blood pressure is substantially above goal. In addition, a combination product may be substituted for individual components in patients currently maintained on both agents separately or in patients not adequately controlled with monotherapy who are currently using one of the agents or an agent within the same antihypertensive drug class. When using a thiazide diuretic, UpToDate generally suggests using chlorthalidone or indapamide rather than hydrochlorothiazide; although, fewer such single-pill combinations are available.
* Combination product components and corresponding doses are listed in the order provided in licensed product labeling.
Data from: UpToDate Lexidrug. More information available at https://online.lexi.com/.
Graphic 139423 Version 7.0

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