Case definitions for mpox | |
Suspected case |
or
|
Probable case | There is no suspicion of other recent orthopoxvirus exposure (eg, vaccinia virus in ACAM2000 vaccination) and:
or
or
|
Confirmed mpox case | Monkeypox virus DNA is detected by polymerase chain reaction testing or next-generation sequencing of a clinical specimen or monkeypox virus is isolated in a culture from a clinical specimen. |
Data used to determine case definition | |
Characteristic rash | New rash (any of the following):*
The characteristic rash associated with mpox lesions involves deep-seated and well-circumscribed lesions, often with central umbilication. Lesions progress through specific sequential stages: macules, papules, vesicles, pustules, and scabs. |
Epidemiologic criteria | Within 21 days of illness onset (any of the following):
|
Laboratory criteria | The following findings on laboratory testing are used to inform the case definition:
|
Exclusion criteria | A case may be excluded as a suspected, probable, or confirmed mpox case if any of the following criteria are met:
|
This table represents the case definitions and clinical and epidemiologic criteria for mpox put forth by the United States Centers for Disease Control and Prevention (CDC) in May 2022. Updated information can be found on the CDC website. Other case definitions may vary. Case definitions put forth by the World Health Organization (WHO) can be found on the WHO website.
In November 2022, the World Health Organization changed the name of the disease referred to as "monkeypox" to "mpox." The virus that causes mpox continues to be referred to as monkeypox virus.LRN: Laboratory Response Network.
* The rash associated with mpox can be confused with other, more common infections (eg, secondary syphilis, herpes simplex virus, chancroid, and varicella zoster virus). Sporadic reports of patients co-infected with monkeypox virus and other infectious agents have been reported (eg, varicella zoster virus, Treponema pallidum).
¶ This includes men who have sex with men who meet partners through an online website, digital applications, or at a social event (eg, bar or party).
Δ Although the 2022 outbreak to date has been primarily reported in men who have sex with men, anyone who has been in close contact with someone who has mpox is at risk.
◊ Other types of animal exposures have also been reported. In 2003, an outbreak of mpox in the United States was associated with prairie dogs who acquired the virus from African rodents.Do you want to add Medilib to your home screen?