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Key genes and pathways involved in the pathogenesis of cutaneous squamous cell carcinoma

Key genes and pathways involved in the pathogenesis of cutaneous squamous cell carcinoma
Gene Frequency of mutation Functions
TP53 66% Canonical tumor suppressor gene, sensor of cellular insults such as DNA damage
NOTCH1/2 36 to 55% Cell-cell signaling, differentiation
FAT1 30% Regulator of stemness, epithelial-mesenchymal transition
CDKN2A 35% Negative regulator of cell cycle progression
DNA: deoxyribonucleic acid.
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