Patients on a stable dose of a serotonergic agent are unlikely to develop serotonin syndrome.
Based on Hunter Toxicity Criteria Decision Rules.
Refer to UpToDate content for further discussion on serotonin syndrome.SSRIs: selective serotonin reuptake inhibitors; SNRIs: serotonin-norepinephrine reuptake inhibitors; MAO: monoamine oxidase; MDMA: 3,4-methylenedioxymethamphetamine (ie, ecstasy).
* Neuromuscular findings typically occur in lower extremities.
¶ Clonus should be greater than 3 beats.
Δ Ocular clonus is slow, continuous, horizontal bilateral eye movements occurring in an unresponsive patient.
◊ Examples of common direct serotonin receptor agonists:
§ SSRIs rarely cause severe serotonin toxicity while medications that inhibit MAO are more likely to cause severe serotonin syndrome.
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