COG: Children's Oncology Group; GTR: gross-total resection; MYCN+: MYCN amplified; MYCN–: MYCN not amplified; FH: favorable histology; DI: DNA index; SCA: segmental chromosomal aberration; UH: unfavorable histology; INPC: International Neuroblastoma Pathology Classifier; v2: version 2; INRG: International Neuroblastoma Risk Group.
* If tumor progresses during observation, biopsy or resect and reclassify with biomarkers (as in COG ANBL1232).
¶ Consider complete resection if feasible.
Δ If no tumor burden symptoms, consider observation (as in COG ANBL1232).
◊ Biopsy contraindicated, defer biopsy until stable (NOTE: Biomarker results may modify risk class).
§ Hepatomegaly alone is an MS symptom in patients age <3 months of age (refer to COG ANBL1232).
¥ Response-based therapy (as in COG ANBL1232).
‡ MS score-based therapy (as in COG ANBL1232).Do you want to add Medilib to your home screen?