- Contacts of people with confirmed or suspected contagious TB (contact investigation)
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- Children with radiographic or clinical findings suggesting TB disease
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- Children immigrating from countries with endemic infection (eg, Asia, Middle East, Africa, Latin America, countries of the former Soviet Union), including international adoptees
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- Children with history of significant travel* to countries with endemic infection who have substantial contact with the resident population
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- Children with HIV infection
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- Children with other medical conditions, including diabetes mellitus, chronic renal failure, malnutrition, or congenital or acquired immunodeficiencies and children receiving TNF-a antagonists, which may enhance the possibility for progression to severe disease
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